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Start free with EleplanNarcolepsy type 1
ORPHA:2073Disease
Also called Gélineau disease · Hypocretin/orexin deficiency syndrome · Narcolepsy-cataplexy
What it is
A rare neurologic disease characterized by excessive daytime sleepiness associated with uncontrollable sleep urges and cataplexy (sudden loss of muscle tone while awake, often triggered by pleasant emotions).
Key facts
- Prevalence
- 1-5 / 10 000 (Europe)
- Age of onset
- Adolescent, Adult, Childhood
- Inheritance
- Unknown
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
5Common30–79%
15- Abnormal pupillary function
- Abnormal rapid eye movement sleep
- Anxiety
- Attention deficit hyperactivity disorder
- Constipation
- Drooling
- Female sexual dysfunction
- Hyperhidrosis
- Hypertension
- Hypnagogic hallucinations
- Hypnopompic hallucinations
- Male sexual dysfunction
- Nocturia
- Non-rapid eye movement parasomnia
- Restless legs
Sometimes5–29%
9and 1 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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