Rare diseases · Sign or symptom
Obesity
Having too much body fat
HP:0001513
What it means
Accumulation of substantial excess body fat.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this160
Always100%
7Very common80–99%
38- 1p21.3microdeletion syndrome
- 6q16microdeletion syndrome
- Adenocarcinoma of the oesophagus and oesophagogastric junction
- Adiposis dolorosa
- Ahmad syndrome
- Alström syndrome
- Aromatase deficiency
- Atkin-Flaitz syndrome
- Bardet-Biedl syndrome
- Biemond syndrome type 2
- Carpenter syndrome
- Cognitive impairment-coarse facies-heart defects-obesity-pulmonary involvement-short stature-skeletal dysplasia syndrome
- Hernández-Aguirre Negrete syndrome
- HIDEA syndrome
- Hypogonadism-mitral valve prolapse-intellectual disability syndrome
- Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome
- Intellectual disability-seizures-macrocephaly-obesity syndrome
- Laurence-Moon syndrome
- MEHMO syndrome
- Microtriplication 11q24.1 syndrome
- Monosomy 13q34 syndrome
- Morgagni-Stewart-Morel syndrome
- Obesity due to SIM1 deficiency
- Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
- Prader-Willi syndrome due to translocation
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency
- SIM1-related Prader-Willi-like syndrome
- Smith-Magenis syndrome
- Thyrotoxic periodic paralysis
- Trisomy 5p syndrome
- Urban-Rogers-Meyer syndrome
- X-linked intellectual disability-hypogonadism-ichthyosis-obesity-short stature syndrome
- X-linked intellectual disability, Shashi type
- X-linked intellectual disability, Stevenson type
Common30–79%
35- 14q11.2microduplication syndrome
- 2q37microdeletion syndrome
- 3q29microduplication syndrome
- 48,XXYY syndrome
- Angelman syndrome
- Angelman syndrome due to a point mutation
- Angelman syndrome due to imprinting defect in 15q11-q13
- Angelman syndrome due to maternal 15q11q13 deletion
- Ankylosing vertebral hyperostosis with tylosis
- Ataxia-oculomotor apraxia type 4
- Beckwith-Wiedemann syndrome
- Cohen syndrome
- Colobomatous microphthalmia-obesity-hypogenitalism-intellectual disability syndrome
- Craniopharyngioma
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome
- Distal 16p11.2 microdeletion syndrome
- Down syndrome
- Dysbetalipoproteinemia
- Hydrocephalus-costovertebral dysplasia-Sprengel anomaly syndrome
- Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency
- Hypogonadotropic hypogonadism-retinitis pigmentosa syndrome
- Idiopathic intracranial hypertension
- Intellectual disability-obesity-prognathism-eye and skin anomalies syndrome
- Kleefstra syndrome
- Kleefstra syndrome due to 9q34 microdeletion
- Male hypergonadotropic hypogonadism-intellectual disability-skeletal anomalies syndrome
- Microcephalic primordial dwarfism, Dauber type
- Microduplication Xp11.22p11.23 syndrome
- Monosomy X syndrome
- Mosaic monosomy X syndrome
- Müllerian aplasia and hyperandrogenism
- MYT1L-related developmental delay-intellectual disability-obesity syndrome
- Obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome
- Paternal uniparental disomy of chromosome 1 syndrome
- Prader-Willi syndrome due to imprinting mutation
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 2 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.