Rare diseases · Sign or symptom
Drooling
Dribbling
HP:0002307
What it means
Habitual flow of saliva out of the mouth.
Rare diseases that can present with this51
Common30–79%
23- 4H leukodystrophy
- Acute inflammatory demyelinating polyradiculoneuropathy
- Amyotrophic lateral sclerosis
- Angelman syndrome
- Angelman syndrome due to maternal 15q11q13 deletion
- Christianson syndrome
- FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome
- FG syndrome type 1
- Infantile-onset generalized dyskinesia with orofacial involvement
- Megalencephaly-severe kyphoscoliosis-overgrowth syndrome
- Narcolepsy type 1
- Neuroleptic malignant syndrome
- PFAPA syndrome
- Postnatal microcephaly-infantile hypotonia-spastic diplegia-dysarthria-intellectual disability syndrome
- PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome
- Rapid-onset dystonia-parkinsonism
- Rolandic epilepsy-speech dyspraxia syndrome
- SATB2-associated syndrome due to a chromosomal rearrangement
- SATB2-associated syndrome due to a pathogenic variant
- Self-limited epilepsy with centrotemporal spikes
- Severe intellectual disability and progressive spastic paraplegia
- Worster-Drought syndrome
- X-linked alpha-thalassemia-intellectual disability syndrome
Sometimes5–29%
25- 11q22.2q22.3microdeletion syndrome
- 21q22.11q22.12microdeletion syndrome
- 7q11.23microduplication syndrome
- Angelman syndrome due to a point mutation
- Angelman syndrome due to imprinting defect in 15q11-q13
- Aromatic L-amino acid decarboxylase deficiency
- Ataxia-telangiectasia-like disorder
- Bilateral perisylvian polymicrogyria
and 17 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Sialorrhea
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.