Rare diseases · Sign or symptom
Decreased body weight
Decreased weight
HP:0004325
What it means
Abnormally low body weight.
Rare diseases that can present with this39
Very common80–99%
7Common30–79%
21- 20p13microdeletion syndrome
- Autosomal recessive spastic paraplegia type 63
- Donohue syndrome
- Early-onset seizures-distal limb anomalies-facial dysmorphism-global developmental delay syndrome
- FOXG1 syndrome
- Hemorrhagic fever-renal syndrome
- Insulin-resistance syndrome type B
- Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
- Maternal uniparental disomy of chromosome 20 syndrome
- Maternal uniparental disomy of chromosome 4 syndrome
- Mowat-Wilson syndrome
- Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome
- Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome
- Pyruvate dehydrogenase E1-beta deficiency
- Ramos-Arroyo syndrome
- Ring chromosome 11 syndrome
- Sepsis in premature infants
- Short ulna-dysmorphism-hypotonia-intellectual disability syndrome
- Silver-Russell syndrome due to an imprinting defect of 11p15
- Wolcott-Rallison syndrome
- X-linked intellectual disability, Porteous type
Sometimes5–29%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Low body weight · Low weight · Weight less than 3rd percentile
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.