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Start free with EleplanAcute promyelocytic leukemia
ORPHA:520Disease
Also called AML M3 · AML with t(15;17)(q22;q12);(PML/RARalpha) and variants · APML · Acute myeloblastic leukemia 3 · Acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants
What it is
An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells, and manifests with easy bruising, hemorrhagic diathesis and fatigue.
Key facts
- Prevalence
- 1-9 / 1 000 000 (annual incidence, Europe)
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Inheritance
- Not applicable
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Common30–79%
21Sometimes5–29%
12- Abdominal pain
- Alcoholism
- Bone pain
- Decreased total neutrophil count
- Diffuse alveolar hemorrhage
- Gingival overgrowth
- Hypofibrinogenemia
- Increased total leukocyte count
and 4 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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