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Start free with EleplanGRFoma
ORPHA:97261Disease
Also called GRF tumor · Growth hormone releasing factor tumor
What it is
GRFoma is a type of pancreatic endocrine tumor that hypersecretes growth hormone-releasing factor (GRF or GHRH) and that clinically resembles a pituitary adenoma as patients present with acromegaly. In addition to the pancreas, this tumor can also occur in the lungs or small intestine, are usually large > 6cm and approximately 1/3 have metastasized at the time of diagnosis. It often co-occurs with Zollinger-Ellison syndrome or multiple endocrine neoplasia type 1 (MEN 1).
Key facts
- Age of onset
- Adult
- Inheritance
- Not applicable
- Classified as
- Disease
Signs and symptoms
Common30–79%
16- Abnormality of abdomen morphology
- Anorexia
- Coarse facial features
- Constipation
- Diarrhea
- Episodic abdominal pain
- Hepatomegaly
- Hypoactive bowel sounds
- Increased circulating cortisol level
- Nausea and vomiting
- Neoplasm of the lung
- Neoplasm of the pancreas
- Palmoplantar hyperhidrosis
- Poor appetite
- Weight loss
- Zollinger-Ellison syndrome
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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