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Start free with EleplanManganese poisoning
ORPHA:306682Disease
Also called Manganese intoxication · Manganism
What it is
A rare disorder due to toxic effects characterized by a progressive, permanent affliction of the extrapyramidal system with the globus pallidus and striatum as primary targets of neurotoxic effects. Symptoms include headache, insomnia, memory loss, emotional instability, hyperreflexia, dystonia, tremor, speech disturbances, and gait abnormalities. Individual factors like age, gender, genetics, and pre-existing medical conditions appear to have a profound impact on manganese toxicity.
Key facts
- Age of onset
- All ages
- Classified as
- Disease
Signs and symptoms
Very common80–99%
15- Abnormal globus pallidus morphology
- Abnormality of extrapyramidal motor function
- Abnormality of mitochondrial metabolism
- Bradykinesia
- Cogwheel rigidity
- Dystonia
- Emotional lability
- Gait disturbance
- Headache
- Hypertonia
- Increased reactive oxygen species production
- Memory impairment
- Postural instability
- Postural tremor
- Sleep-wake cycle disturbance
Common30–79%
10These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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