Rare diseases · Sign or symptom
Sleep-wake cycle disturbance
HP:0006979
What it means
Any abnormality of an individual's circadian rhythm that affects the timing of sleeping and being awake is referred to as a sleep-wake disorder.
Often, patients complain of insomnia when their desired sleep-wake cycle is inconsistent with their intrinsic rhythms.
Rare diseases that can present with this17
Common30–79%
10The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Internal-clock disorders · Sleep phase disturbance · Sleep-wake cycle disorders · Sleep-wake mistiming
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.