Rare diseases · Sign or symptom
Bradykinesia
Slow movements
HP:0002067
What it means
Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement).
Rare diseases that can present with this61
Very common80–99%
4Common30–79%
40- Adult-onset nemaline myopathy
- Atypical progressive supranuclear palsy syndrome
- Autosomal dominant progressive external ophthalmoplegia
- Autosomal recessive dopa-responsive dystonia
- Beta-propeller protein-associated neurodegeneration
- Bilateral striopallidodentate calcinosis
- Childhood-onset nemaline myopathy
- Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome
- Classic progressive supranuclear palsy syndrome
- CLN12 disease
- Corticobasal syndrome
- Cyanide-induced parkinsonism-dystonia
- Delayed encephalopathy due to carbon monoxide poisoning
- Dopa-responsive dystonia due to sepiapterin reductase deficiency
- Dravet syndrome
- Dystonia 16
- Dystonia-parkinsonism-hypermanganesemia syndrome
- Hemiparkinsonism-hemiatrophy syndrome
- Huntington disease
- Infantile dystonia-parkinsonism
- Inherited Creutzfeldt-Jakob disease
- Juvenile Huntington disease
- Mitochondrial membrane protein-associated neurodegeneration
- Multiple system atrophy
- Multiple system atrophy, parkinsonian type
- Neuroferritinopathy
- Parkinsonian-pyramidal syndrome
- PLA2G6-related neurodegeneration, adult-onset
- Postencephalitic parkinsonism
- Primary progressive freezing gait
- PRKAR1B-related neurodegenerative dementia with intermediate filaments
- Progressive supranuclear palsy
- Progressive supranuclear palsy-predominant parkinsonism syndrome
- Rapid-onset dystonia-parkinsonism
- Rett syndrome
- Spinocerebellar ataxia type 1
- Spinocerebellar ataxia type 20
- Spinocerebellar ataxia type 8
- X-linked dystonia-parkinsonism
- X-linked parkinsonism-spasticity syndrome
Sometimes5–29%
13- 6-pyruvoyl-tetrahydropterin synthase deficiency
- Autosomal dominant dopa-responsive dystonia
- Autosomal recessive progressive external ophthalmoplegia
- Autosomal recessive spastic paraplegia type 77
- Choreoacanthocytosis
- Fragile X-associated tremor/ataxia syndrome
- Hereditary late-onset Parkinson disease
- Huntington disease-like 1
and 5 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Slowness of movements
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.