Rare diseases · Sign or symptom
Aggressive behavior
Aggression
HP:0000718
What it means
Behavior or an act aimed at harming a person, animal, or physical property (e.g., acts of physical violence; shouting, swearing, and using harsh language; slashing someone's tires).
Rare diseases that can present with this118
Very common80–99%
9- 3-methylglutaconic aciduria type 9
- 48,XYYY syndrome
- Behavioral variant of frontotemporal dementia
- Distal Xq28 microduplication syndrome
- Global developmental delay-osteopenia-ectodermal defect syndrome
- Wilson disease
- X-linked epilepsy-learning disabilities-behavior disorders syndrome
- X-linked intellectual disability-hypotonia-facial dysmorphism-aggressive behavior syndrome
- X-linked intellectual disability-psychosis-macroorchidism syndrome
Common30–79%
37- 11p15.4microduplication syndrome
- 14q11.2microduplication syndrome
- ANK3-related intellectual disability-sleep disturbance syndrome
- Autosomal recessive spastic paraplegia type 64
- Citrullinemia type II
- CK syndrome
- Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to 10p11.21p12.31 microdeletion
- FRAXE intellectual disability
- Fried syndrome
- Global developmental delay-alopecia-macrocephaly-facial dysmorphism-structural brain anomalies syndrome
- Hao-Fountain syndrome due to 16p13.2 microdeletion
- Houge-Janssens syndrome type 1
- Huntington disease
- Intellectual disability-epilepsy-extrapyramidal syndrome
- KDM5C-related syndromic X-linked intellectual disability
- Kleefstra syndrome
- Lennox-Gastaut syndrome
- Manganese poisoning
- MORM syndrome
- Myoclonic epilepsy of infancy
- MYT1L-related developmental delay-intellectual disability-obesity syndrome
- Non-progressive cerebellar ataxia with intellectual disability
- PCDH19 clustering epilepsy
- Progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- SATB2-associated syndrome due to a chromosomal rearrangement
- Severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency
- Severe intellectual disability-short stature-behavioral abnormalities-facial dysmorphism syndrome
- Spinocerebellar ataxia type 27A
- Tuberous sclerosis complex
- WARS2-related combined oxidative phosphorylation defect
- Wiedemann-Steiner syndrome
- X-linked adrenoleukodystrophy
- X-linked intellectual disability-acromegaly-hyperactivity syndrome
- X-linked intellectual disability, Cabezas type
- X-linked intellectual disability-hypotonia-movement disorder syndrome
- X-linked intellectual disability, Nascimento type
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Aggressiveness · physical aggression
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.