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Start free with EleplanEthylene glycol poisoning
ORPHA:31826Disease
What it is
A rare poisoning resulting in elevated anion gap metabolic acidosis, due to the production of glycolic acid, glyoxylic acid, and oxalic acid by alcohol dehydrogenase (ADH) in the liver when ethylene glycol is metabolized, characterized initially by euphoria, slurred speech, encephalopathy, coma and seizures, and followed by late manifestations such as tachycardia, arrhythmias, myocardial depression, hemodynamic imbalance and, finally, acute renal failure.
Key facts
- Age of onset
- All ages
- Inheritance
- Not applicable
- Classified as
- Disease
Signs and symptoms
Common30–79%
11Sometimes5–29%
17- Abnormal pattern of respiration
- Abnormal pupillary light reflex
- Alcoholism
- Atrial fibrillation
- Coma
- Congestive heart failure
- Cyanosis
- Episodic respiratory distress
and 9 more in this range
Rare1–4%
14- Abnormal cranial nerve physiology
- Cerebral edema
- Decreased urine output
- Encephalopathy
- Facial palsy
- Flank pain
- Hematuria
- Hypothermia
and 6 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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