Rare diseases · Sign or symptom
Hypothermia
Abnormally low body temperature
HP:0002045
What it means
Reduced body temperature due to failed thermoregulation.
A condition in which core temperature drops below that required for normal metabolism and body functions which is defined as 35.0 degrees C (95.0 degrees F).
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this36
Very common80–99%
2Common30–79%
9- Alexander disease
- Congenital hypothyroidism due to maternal intake of antithyroid drugs
- Hypothyroidism due to deficient transcription factors involved in pituitary development or function
- Isolated thyroid-stimulating hormone deficiency
- Occipital horn syndrome
- Ornithine transcarbamylase deficiency
- PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Sepsis in premature infants
Sometimes5–29%
16- Adult-onset autosomal dominant leukodystrophy
- Carnitine-acylcarnitine translocase deficiency
- Dopamine beta-hydroxylase deficiency
- Familial thyroid dyshormonogenesis
- Fatal infantile lactic acidosis with methylmalonic aciduria
- Idiopathic congenital hypothyroidism
- Isovaleric acidemia
- Marburg hemorrhagic fever
and 8 more in this range
Rare1–4%
9- 3-hydroxy-3-methylglutaric aciduria
- Congenital enterovirus infection
- Ethylene glycol poisoning
- Genetic transient congenital hypothyroidism
- Hereditary sensory and autonomic neuropathy type 4
- Hypothyroidism due to TSH receptor mutations
- Invasive meningococcal disease
- Neuroleptic malignant syndrome
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.