Rare diseases · Sign or symptom
Hypocalcemia
Low blood calcium levels
HP:0002901
What it means
The concentration of calcium in the blood circulation is below the lower limit of normal.
Rare diseases that can present with this53
Always100%
2Very common80–99%
15- Autoimmune hypoparathyroidism
- Autosomal dominant hypocalcemia
- Autosomal recessive Kenny-Caffey syndrome
- Cartilage-hair hypoplasia
- Dahlberg-Borer-Newcomer syndrome
- Familial isolated hypoparathyroidism
- Hypocalcemic vitamin D-resistant rickets
- Kidney tubulopathy-dilated cardiomyopathy syndrome
- Müllerian derivatives-lymphangiectasia-polydactyly syndrome
- Pseudohypoparathyroidism type 1A
- Pseudohypoparathyroidism type 1B
- Pseudohypoparathyroidism type 1C
- Pseudohypoparathyroidism type 2
- Ring chromosome 10 syndrome
- Sanjad-Sakati syndrome
Common30–79%
13- 22q11.2deletion syndrome
- 2p21microdeletion syndrome
- Alpha-heavy chain disease
- Cholera
- Colchicine poisoning
- Cystinosis
- Ethylene glycol poisoning
- Hypoparathyroidism-sensorineural deafness-renal disease syndrome
- Mitochondrial trifunctional protein deficiency
- Osteopetrosis with renal tubular acidosis
- Progressive familial intrahepatic cholestasis
- Secondary hypoparathyroidism due to impaired parathormon secretion
- X-linked agammaglobulinemia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 3 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased calcium(2+) concentration · Decreased calcium(2+) level · Decreased calcium(2+) level in blood · Hypocalcaemia · Reduced calcium(2+) concentration · Reduced calcium(2+) level · Reduced calcium(2+) level in blood
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.