Rare diseases · Sign or symptom

Euphoria

HP:0031844

What it means

Elevation of emotional tone or mood that significantly deviates from normative affective functioning. This state is characterized by an overwhelming and all-encompassing sense of joyous well-being; it is associated with unfounded grandiosity, or grossly inflated self-esteem, rapid speech, impulsivity, and an impaired capacity for self-regulation, irrespective of context.

Euphoria may be experienced in the course of normal human activity, including sporting victory, sexual, substance use, or communal spiritual experiences; all manifestations of euphoria refer to profound elation and positive mood experiences. Euphoria in the normal context, is typically very brief and short-lived. Severe pathological euphoria may last hours to days and frequently results in marked impairments in judgment, behavior, and social or occupational functioning.

Rare diseases that can present with this2

Sometimes5–29%

1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Abnormally elevated mood · Euphoric mood · Excessive joyfulness · Extreme elation · Hyperthymia · Hyperthymic state · Inappropriate elation · Inappropriately happy

Euphoria

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.