Rare diseases · Sign or symptom
Epistaxis
Bloody nose
HP:0000421
What it means
Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.
Rare diseases that can present with this66
Very common80–99%
9Common30–79%
17- 9q33.3q34.11microdeletion syndrome
- Acute promyelocytic leukemia
- Bleeding disorder in hemophilia A carriers
- Combined deficiency of factor V and factor VIII
- Congenital factor II deficiency
- Congenital factor V deficiency
- Congenital factor VII deficiency
- Congenital factor X deficiency
- Congenital factor XI deficiency
- Crimean-Congo hemorrhagic fever
- Evans syndrome
- Gray platelet syndrome
- Hermansky-Pudlak syndrome
- Juvenile nasopharyngeal angiofibroma
- Scott syndrome
- Severe hemophilia A
- Von Willebrand disease
Sometimes5–29%
35- Acquired von Willebrand syndrome
- Adrenocortical carcinoma with pure aldosterone hypersecretion
- Autoerythrocyte sensitization syndrome
- Autosomal dominant macrothrombocytopenia
- Capillary malformation-arteriovenous malformation
- Chédiak-Higashi syndrome
- Chikungunya
- Congenital factor XIII deficiency
and 27 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Frequent nosebleeds · Nasal haemorrhage · Nasal hemorrhage · Nose bleed · Nose bleeding · Nosebleed
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.