Rare diseases · Sign or symptom
Hypofibrinogenemia
HP:0011900
What it means
Decreased concentration of fibrinogen in the blood.
Rare diseases that can present with this21
Common30–79%
12- Acquired hemophagocytic lymphohistiocytosis associated with malignant disease
- Acquired purpura fulminans
- Familial hemophagocytic lymphohistiocytosis
- HELLP syndrome
- Heme oxygenase-1 deficiency
- Hemophagocytic syndrome associated with an infection
- Hereditary spherocytosis
- Kaposiform hemangioendothelioma
- Kaposiform lymphangiomatosis
- Macrophage activation syndrome
- Maternal uniparental disomy of chromosome 4 syndrome
- S-adenosylhomocysteine hydrolase deficiency
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Low fibrinogen activity · Low fibrinogen level
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.