Young-onset Parkinson disease

Caring for someone with this diagnosis? Eleplan keeps diagnoses, medications, documents and every specialist in one plan.

Start free with Eleplan

Young-onset Parkinson disease

ORPHA:2828Disease

Also called Early-onset Parkinson disease · YOPD

What it is

A rare parkinsonian disorder characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most forms of this disease.

Key facts

Prevalence
1-5 / 10 000 (Europe)
Age of onset
Adult
Inheritance
Autosomal recessive
Classified as
Disease

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Genes

DNAJC6Disease-causing germline mutation(s) (loss of function)
PARK7Disease-causing germline mutation(s)
PINK1Disease-causing germline mutation(s)
PODXLDisease-causing germline mutation(s) (loss of function)
PRKNDisease-causing germline mutation(s)
SYNJ1Disease-causing germline mutation(s)
VPS13CDisease-causing germline mutation(s) (loss of function)
HTRA2Candidate gene tested
LRRK2Candidate gene tested
SNCACandidate gene tested
UCHL1Candidate gene tested

ICD-10 codes

G20filed under a broader ICD-10 category — shared with 9 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Benefit programs to look at

Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.

Cross-references

MONDO 0017279OMIM 300557OMIM 600116OMIM 602404OMIM 605909OMIM 606324OMIM 606852OMIM 610297OMIM 613643OMIM 615528OMIM 616840UMLS C4275179

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

Powered by Eleplan

A rare diagnosis is just the start. Eleplan keeps the whole care plan in one place.

Diagnoses, medications, documents, appointments, and the whole care team — organized and always in sync, so you are not retelling the same story to every new specialist. With Ellie, your AI care assistant, on top of it. Free to start.