Rare diseases · Sign or symptom
Type I diabetes mellitus
Type 1 diabetes
HP:0100651
What it means
A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin.
The onset of type 1 diabetes is typically during adolescence, but it can develop at any age.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this39
Very common80–99%
7Common30–79%
11- Autoimmune polyendocrinopathy type 1
- Autoimmune polyendocrinopathy type 3
- Autoimmune polyendocrinopathy type 4
- Enteric anendocrinosis
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
- Late-onset isolated ACTH deficiency
- Lipodystrophy due to peptidic growth factors deficiency
- Maternal uniparental disomy of chromosome 1 syndrome
- Renal-hepatic-pancreatic dysplasia
- Scalp-ear-nipple syndrome
- STAT1-related autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome
Sometimes5–29%
11- Addison disease
- Alopecia totalis
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Congenital rubella syndrome
- MELAS
- Multicentric osteolysis-nodulosis-arthropathy spectrum
- PAPA syndrome
- Primary sclerosing cholangitis
and 3 more in this range
Rare1–4%
10- Acatalasemia
- Alopecia universalis
- Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
- Autosomal dominant hyperinsulinism due to SUR1 deficiency
- Autosomal recessive cerebellar ataxia due to STUB1 deficiency
- Combined immunodeficiency-multiple intestinal atresia
- Gitelman syndrome
- Maternal uniparental disomy of chromosome 4 syndrome
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Diabetes mellitus Type I · Insulin-dependent diabetes mellitus · Juvenile diabetes mellitus · Type I diabetes
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.