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Start free with EleplanAutoimmune polyendocrinopathy type 3
ORPHA:227982Disease
Also called APS type 3 · APS3 · Autoimmune polyendocrine syndrome type 3 · Autoimmune polyglandular syndrome type 3
What it is
A rare, endocrine disease characterized by autoimmune thyroid disease associated with at least one other autoimmune disease, such as type I diabetes mellitus, chronic atrophic gastritis, pernicious anemia, vitiligo, alopecia, or myasthenia gravis, but excluding Addison disease.
Key facts
- Age of onset
- All ages
- Inheritance
- Multigenic/multifactorial
- Classified as
- Disease
Signs and symptoms
Common30–79%
7- Atrophic gastritisDiagnostic criterion
- Autoimmune antibody positivity
- Celiac disease
- Graves diseaseDiagnostic criterion
- Hashimoto thyroiditisDiagnostic criterion
- Macrocytic anemia
- Type I diabetes mellitusDiagnostic criterion
Sometimes5–29%
6- AlopeciaDiagnostic criterion
- Anterior pituitary dysgenesis
- Biliary cirrhosis
- Decreased circulating antibody level
- Leukopenia
- VitiligoDiagnostic criterion
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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