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Start free with EleplanCongenital rubella syndrome
ORPHA:290Disease
Also called CRS · Fetal rubella syndrome · Mother-to-child transmission of rubella syndrome
What it is
An infectious embryofetopathy that may present in an infant as a result of maternal infection early in pregnancy and subsequent fetal infection with rubella virus. The disorder can lead to deafness, cataract, and variety of other permanent manifestations including cardiac and neurological defects.
Key facts
- Prevalence
- 1-9 / 1 000 000 (at birth)
- Age of onset
- Antenatal, Neonatal
- Inheritance
- Not applicable
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
4Common30–79%
22- Abnormality of retinal pigmentation
- Abnormality of the fontanelles or cranial sutures
- Abnormality of the pulmonary artery
- Anemia
- Aplasia/Hypoplasia of the iris
- Atrial septal defect
- Glaucoma
- Hepatomegaly
- Hypotonia
- Intellectual disability
- Microcephaly
- Microphthalmia
- Nystagmus
- Patent ductus arteriosus
- Short stature
- Skin rash
- Spastic diplegia
- Splenomegaly
- Strabismus
- Thrombocytopenia
- Ventricular septal defect
- Visual impairment
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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