Rare diseases · Sign or symptom
Speech articulation difficulties
HP:0009088
What it means
Impairment in the physical production of speech sounds.
Speech articulation difficulties can result from abnormalities of the vocal tract (the larynx and the pharyngeal, oral, and nasal cavities).
Rare diseases that can present with this26
Very common80–99%
3Common30–79%
14- Atypical progressive supranuclear palsy syndrome
- Classic galactosemia
- Cleft lip and alveolus
- Cleft lip/palate
- Huntington disease
- Landau-Kleffner syndrome
- Neurofibromatosis type 1 due to NF1 mutation or intragenic deletion
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
- Progressive supranuclear palsy-progressive non-fluent aphasia syndrome
- Proximal 16p11.2 microdeletion syndrome
- Self-limited epilepsy with centrotemporal spikes
- Xq25microduplication syndrome
Sometimes5–29%
9- Cleft velum
- Developmental and epileptic encephalopathy with spike-wave activation in sleep
- Florid cemento-osseous dysplasia
- Hyperprolinemia type 2
- Isolated cleft lip
- Pantothenate kinase-associated neurodegeneration
- Progressive supranuclear palsy-corticobasal syndrome
- Snakebite envenomation
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.