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Start free with EleplanDevelopmental and epileptic encephalopathy with spike-wave activation in sleep
ORPHA:725Disease
Also called Epileptic encephalopathy with continuous spike-and-wave during slow sleep · Epileptic encephalopathy with spike-and wave activation in sleep · CSWS · CSWSS syndrome · Continuous spikes and waves during sleep · Continuous spikes and waves during slow-wave sleep · DEE-SWAS
What it is
Continuous spikes and waves during sleep (CSWS) is a rare epileptic encephalopathy of childhood characterized by seizures, an electroencephalographic (EEG) pattern of electrical status epilepticus in sleep (ESES) and neurocognitive regression in at least 2 domains of development.
Key facts
- Age of onset
- Childhood
- Inheritance
- Autosomal dominant, Not applicable
- Classified as
- Disease
Signs and symptoms
Very common80–99%
3Common30–79%
12- Atypical absence seizure
- Bilateral tonic-clonic seizure
- Cognitive impairment
- Developmental regression
- EEG with centrotemporal focal spike waves
- EEG with frontal focal spike waves
- Focal aware seizure
- Focal hemiclonic seizure
- Focal impaired awareness seizure
- Focal motor seizure
- Focal-onset seizure
- Intellectual disability
Sometimes5–29%
15- Aggressive behavior
- Aphasia
- Atonic seizure
- Autistic behavior
- Clumsiness
- Dystonia
- EEG with generalized polyspikes
- Focal clonic seizure
and 7 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Benefit programs to look at
Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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