Rare diseases · Sign or symptom
Language impairment
HP:0002463
What it means
Language impairment is a deficit in comprehension or production of language that includes reduced vocabulary, limited sentence structure, or impairments in written or spoken communication. Language abilities are substantially and quantifiably below age expectations.
Rare diseases that can present with this39
Very common80–99%
8Common30–79%
11- 16p13.11microduplication syndrome
- 17q11microdeletion syndrome
- 2q31.1microdeletion syndrome
- 8p23.1duplication syndrome
- Bilateral frontoparietal polymicrogyria
- Bilateral perisylvian polymicrogyria
- Bilateral polymicrogyria
- Cleft hard palate
- Glioblastoma
- Lissencephaly due to LIS1 mutation
- PRKAR1B-related neurodegenerative dementia with intermediate filaments
Sometimes5–29%
19- 16p11.2p12.2microduplication syndrome
- 17q12microdeletion syndrome
- 17q12microduplication syndrome
- Amyotrophic lateral sclerosis
- CADASIL
- Distal 22q11.2 microduplication syndrome
- Dural sinus malformation with arteriovenous shunt
- Familial or sporadic hemiplegic migraine
and 11 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Language disorder
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.