Rare diseases · Sign or symptom
Inflammatory abnormality of the skin
Skin inflammation
HP:0011123
What it means
The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes.
Rare diseases that can present with this29
Very common80–99%
8Common30–79%
11- Benign cephalic histiocytosis
- Chilblain lupus
- Familial reactive perforating collagenosis
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
- Panniculitis-induced localized lipodystrophy
- Postinfectious vasculitis
- Pressure-induced localized lipoatrophy
- Refractory celiac disease
- STAT1-related autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome
- T-B-NK- severe combined immunodeficiency due to adenosine deaminase deficiency
- Verrucous venous malformation
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Abnormal tendency to infections of the skin · Inflammatory skin disease
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.