Rare diseases · Sign or symptom
Pustule
Pimple
HP:0200039
What it means
A small elevation of the skin containing cloudy or purulent material usually consisting of necrotic inflammatory cells.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this34
Very common80–99%
15- Acrodermatitis enteropathica
- Acute generalized exanthematous pustulosis
- Bullous impetigo
- Erosive pustular dermatosis of the scalp
- Hereditary acrokeratotic poikiloderma
- Immunoglobulin A vasculitis
- Inherited epidermodysplasia verruciformis
- Lipoid proteinosis
- Majeed syndrome
- PAPA syndrome
- Papillon-Lefèvre syndrome
- Quinquaud folliculitis decalvans
- Reactive arthritis
- SAPHO syndrome
- Subcorneal pustular dermatosis
Common30–79%
6Sometimes5–29%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Pustula · Pustular lesion · Pustules · Skin pustule · Skin pustules
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.