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Start free with EleplanComplex regional pain syndrome
ORPHA:83452Disease
Also called Sudeck's atrophy · Causalgia · Reflex sympathetic dystrophy · Algodystrophy · Algoneurodystrophy
What it is
A rare neurologic disease characterized by persistent pain that is disproportionate to the inciting event. The pain is regional, usually affecting a limb with a distal predominance, and may occur spontaneously or be stimulus-induced. It is associated with sensory disturbances, vasomotor abnormalities (including changes in skin color and temperature), sudomotor abnormalities, edema, and motor or trophic changes. Symptoms often develop following trauma, fractures, immobilization, surgery, or nerve injury, and their severity and clinical presentation can vary considerably among patients.
Key facts
- Prevalence
- 1-5 / 10 000 (annual incidence, Netherlands)
- Age of onset
- All ages
- Inheritance
- Not applicable
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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