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Start free with EleplanActivated PI3K-delta syndrome 2
ORPHA:693681Disease
Also called APDS type 2 · APDS2 · Activated p110delta syndrome, type 2 · Activated phosphoinositide 3-kinase delta syndrome type 2 · PASLI-R1 · Senescent T-cells-lymphadenopathy-immunodeficiency syndrome due to p110delta-activating mutations, type 2
What it is
Orphanet has not published a description for this disease yet. The identifiers, classification and cross-references below are still current.
Key facts
- Inheritance
- Autosomal dominant
- Classified as
- Disease
Recorded for the broader condition
- Age of onset
- Adult, Childhood, InfancyActivated PI3K-delta syndrome
Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.
Signs and symptoms
Common30–79%
12Sometimes5–29%
9- Autoimmunity
- Chronic active Epstein-Barr virus infection
- Chronic intestinal candidiasis
- Conjunctivitis
- Diarrhea
- Hepatomegaly
- Malabsorption
- Molluscum contagiosum
and 1 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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