Rare diseases · Sign or symptom
Increased total eosinophil count
High blood eosinophil count
HP:0001880
What it means
Increased count of eosinophils in the blood.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this41
Very common80–99%
10Common30–79%
10- Acute generalized exanthematous pustulosis
- Aspergillosis
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- IgG4-related ophthalmic disease
- IgG4-related submandibular gland disease
- Netherton syndrome
- Omenn syndrome
- Roifman syndrome
- Systemic mastocytosis with associated hematologic neoplasm
- Wells syndrome
Sometimes5–29%
19- Acute myelomonocytic leukemia
- Autoimmune lymphoproliferative syndrome
- Autosomal dominant severe congenital neutropenia
- Classic Hodgkin lymphoma
- Coccidioidomycosis
- Combined immunodeficiency due to ZAP70 deficiency
- Drug reaction with eosinophilia and systemic symptoms
- Hereditary folate malabsorption
and 11 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Eosinophilia · Increased eosinophil count
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.