Rare diseases · Sign or symptom
Hypernasal speech
Nasal speech
HP:0001611
What it means
A type of speech characterized by the presence of an abnormally increased nasal airflow during speech associated with structural abnormality of the nasal passages.
May be associated with incomplete or weak closure of the velum. Examination is by nasal endoscopy.
Rare diseases that can present with this43
Very common80–99%
10- 22q11.2deletion syndrome
- 2p21microdeletion syndrome
- Brain dopamine-serotonin vesicular transport disease
- De Barsy syndrome
- Flat face-microstomia-ear anomaly syndrome
- Hypotonia-cystinuria syndrome
- Lujan-Fryns syndrome
- Microcephalic osteodysplastic primordial dwarfism type II
- Ptosis-vocal cord paralysis syndrome
- Wrinkly skin syndrome
Common30–79%
19- 22q11.2duplication syndrome
- 8q21.11microdeletion syndrome
- Branchio-oculo-facial syndrome
- Cleft lip and alveolus
- Congenital myasthenic syndrome
- Distal myotilinopathy
- Freeman-Sheldon syndrome
- Koolen-De Vries syndrome
- Macrocephaly-intellectual disability-left ventricular non compaction syndrome
- Microduplication Xp11.22p11.23 syndrome
- Multiple pterygium-malignant hyperthermia syndrome
- Presynaptic congenital myasthenic syndrome
- Progressive external ophthalmoplegia-myopathy-emaciation syndrome
- Soft and hard cleft palate
- Spastic paraplegia type 7
- Submucosal cleft palate
- Triple A syndrome
- Vocal cord and pharyngeal distal myopathy
- X-linked intellectual disability, Snyder type
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hypernasal voice · Nasal voice
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.