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Start free with EleplanDistal myotilinopathy
ORPHA:98911Disease
What it is
A rare, late adult-onset myofibrillar myopathy characterized by progressive distal muscle weakness associated with peripheral neuropathy and hyporeflexia. Ambulation may be lost within a few years.
Key facts
- Prevalence
- 1-9 / 100 000 (Europe)
- Age of onset
- Adult, Elderly
- Inheritance
- Autosomal dominant
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
8Common30–79%
20- Autophagic vacuoles
- Difficulty climbing stairs
- Difficulty standing
- Distal amyotrophy
- Distal muscle weakness
- Dysarthria
- Elevated circulating creatine kinase concentration
- EMG: myopathic abnormalities
- Fatty replacement of skeletal muscle
- Foot dorsiflexor weakness
- Hip flexor weakness
- Hypernasal speech
- Inability to walk
- Increased endomysial connective tissue
- Increased variability in muscle fiber diameter
- Limited elbow flexion
- Limited knee flexion/extension
- Loss of ability to walk in first decade
- Multiple joint contractures
- Muscle stiffness
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Benefit programs to look at
Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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