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Start free with EleplanSpastic paraplegia type 7
ORPHA:99013Disease
Also called SPG7
What it is
A form of hereditary spastic ataxia characterized by an onset usually in adulthood (but ranging from 10-72 years) of progressive bilateral lower limb weakness and spasticity and sometimes predominant cerebellar ataxia. In addition to frequent sphincter dysfunction and decreased vibratory sense at the ankles, manifestations may include optical neuropathy, nystagmus, blepharoptosis, ophthalmoplegia, decreased hearing, scoliosis, pes cavus, motor and sensory neuropathy, muscle atrophy, parkinsonism, and dystonia.
Key facts
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Inheritance
- Autosomal dominant, Autosomal recessive
- Classified as
- Disease
Signs and symptoms
Common30–79%
18- Abnormality of higher mental function
- Abnormal mitochondrial morphology
- Abnormal pyramidal sign
- Attention deficit hyperactivity disorder
- Babinski sign
- Cerebellar atrophy
- Hypernasal speech
- Impaired vibration sensation in the lower limbs
- Lower limb hyperreflexia
- Lower limb hypertonia
- Lower limb muscle weakness
- Nystagmus
- Optic atrophy
- Ragged-red muscle fibers
- Slowed slurred speech
- Somatic sensory dysfunction
- Supranuclear gaze palsy
- Urinary urgency
Sometimes5–29%
7These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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