Rare diseases · Sign or symptom
Decreased circulating IgA concentration
HP:0002720
What it means
Decreased levels of immunoglobulin A (IgA).
Rare diseases that can present with this21
Very common80–99%
3Common30–79%
8- Activated PI3K-delta syndrome 2
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Bloom syndrome
- MOGS-CDG
- T-B-NK+ severe combined immunodeficiency due to DCLRE1C deficiency
- T-B+NK- severe combined immunodeficiency due to gamma chain deficiency
- Transcobalamin II deficiency
- Wolf-Hirschhorn syndrome
Sometimes5–29%
9- Hypohidrotic ectodermal dysplasia with immunodeficiency
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Kabuki syndrome
- Monosomy 18q syndrome
- Primary intestinal lymphangiectasia
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
- Secondary intestinal lymphangiectasia
- Smith-Magenis syndrome
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased circulating IgA level · Decreased IgA · Decreased immunoglobulin A · Gamma-A globulin deficiency · IgA deficiency · Low levels of immunoglobulin A · Reduced IgA levels
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.