Rare diseases · Sign or symptom
Decreased circulating immunoglobulin concentration
Decreased circulating antibody level
HP:0004313
What it means
An abnormally decreased level of immunoglobulin in blood.
In humans, immunoglobulins comprise the five antibody isotypes IgA, IgD, IgE, IgG and IgM.
Rare diseases that can present with this52
Very common80–99%
17- Alopecia antibody deficiency
- Ataxia-telangiectasia
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Bloom syndrome
- Cernunnos-XLF deficiency
- Deficiency in anterior pituitary function-variable immunodeficiency syndrome
- Distal deletion 19p syndrome
- Epilepsy-telangiectasia syndrome
- Hennekam syndrome
- Hereditary folate malabsorption
- ICF syndrome
- Neonatal intrahepatic cholestasis due to citrin deficiency
- Neuronal intestinal pseudoobstruction
- Reticular dysgenesis
- T-B-NK+ severe combined immunodeficiency due to complete RAG1/2 deficiency
- Thymoma-hypogammaglobulinemia syndrome
- X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome
Common30–79%
16- Activated PI3K-delta syndrome
- Aplasia cutis congenita-intestinal lymphangiectasia syndrome
- Combined immunodeficiency with facio-oculo-skeletal anomalies
- Griscelli syndrome
- Immunodeficiency by defective expression of MHC class II
- Lambert syndrome
- MOGS-CDG
- Multiple myeloma
- Primary intestinal lymphangiectasia
- Proximal myotonic myopathy
- Roifman syndrome
- Say-Barber-Miller syndrome
- Skeletal dysplasia-T-cell immunodeficiency-developmental delay syndrome
- Spastic ataxia-corneal dystrophy syndrome
- Transcobalamin II deficiency
- WHIM syndrome
Sometimes5–29%
18- Ataxia-pancytopenia syndrome
- Autoimmune polyendocrinopathy type 3
- Autoimmune polyendocrinopathy type 4
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Cartilage-hair hypoplasia
- Familial hemophagocytic lymphohistiocytosis
- Hypohidrotic ectodermal dysplasia with immunodeficiency
- MGAT2-CDG
and 10 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased antibody level in blood · Decreased immunoglobulin level · Decreased serum immunoglobulin · Hypogammaglobulinemia · Immunoglobulin deficiency · Reduced immunoglobulin levels
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.