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Start free with EleplanEarly-onset autosomal dominant Alzheimer disease
ORPHA:1020Disease
Also called EOFAD · Early-onset familial autosomal dominant Alzheimer disease · Familial Alzheimer disease
What it is
Early-onset autosomal dominant Alzheimer disease (EOAD) is a progressive dementia with reduction of cognitive functions. EOAD presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset, usually before 60 years old.
Key facts
- Prevalence
- 1-9 / 100 000 (Europe)
- Age of onset
- Adult
- Inheritance
- Autosomal dominant
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
15- Abnormal social behavior
- Agitation
- Cerebral cortical atrophyDiagnostic criterion
- Confusion
- DementiaDiagnostic criterion
- Deposits immunoreactive to beta-amyloid proteinDiagnostic criterion
- Hallucinations
- Hypertonia
- Language impairment
- Memory impairmentDiagnostic criterion
- Myoclonus
- Neurodevelopmental abnormality
- Neurofibrillary tangles
- Parkinsonism
- Seizure
Sometimes5–29%
10- Abnormality of higher mental function
- Abnormality of vision
- Aphasia
- Apraxia
- Ataxia
- Dysgraphia
- Finger agnosia
- Intellectual disability
and 2 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Benefit programs to look at
Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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