Hereditary late-onset Parkinson disease

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Hereditary late-onset Parkinson disease

ORPHA:411602Disease

Also called Autosomal dominant late-onset Parkinson disease · LOPD

What it is

Hereditary late-onset Parkinson disease (LOPD) is a form of Parkinson disease (PD), characterized by an age of onset of more than 50 years, tremor at rest, gait complaints and falls, bradykinesia, rigidity and painful cramps. Patients usually present a low risk of developing non motor symptoms, dystonia, dyskinesia and levodopa-induced dyskinesia (LID).

Key facts

Age of onset
Adult, Elderly
Inheritance
Autosomal dominant
Classified as
Disease

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Genes

DNAJC13Disease-causing germline mutation(s) (gain of function)
GBA1Major susceptibility factor
LRRK2Disease-causing germline mutation(s) (gain of function)
SNCADisease-causing germline mutation(s) (gain of function)
VPS35Disease-causing germline mutation(s)
EIF4G1Candidate gene tested
GIGYF2Candidate gene tested

ICD-10 codes

G20filed under a broader ICD-10 category — shared with 9 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Benefit programs to look at

Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.

Cross-references

MONDO 0008199MONDO 8199OMIM 168601OMIM 605543OMIM 607060OMIM 607688OMIM 614203OMIM 614251OMIM 616361UMLS C4274355

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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