Rare diseases · Sign or symptom
Difficulty climbing stairs
Difficulty walking up stairs
HP:0003551
What it means
Reduced ability to climb stairs.
Rare diseases that can present with this40
Very common80–99%
4Common30–79%
24- Adenylosuccinate synthetase-like 1-related distal myopathy
- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Alpha-dystroglycan-related limb-girdle muscular dystrophy R16
- Alpha-sarcoglycan-related limb-girdle muscular dystrophy R3
- Autosomal dominant adult-onset proximal spinal muscular atrophy
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- Autosomal recessive centronuclear myopathy
- Chronic inflammatory demyelinating polyneuropathy
- Distal myotilinopathy
- DNAJB6-related limb-girdle muscular dystrophy D1
- Gamma-sarcoglycan-related limb-girdle muscular dystrophy R5
- Glycogen storage disease due to acid maltase deficiency
- GMPPB-related limb-girdle muscular dystrophy R19
- Mitochondrial trifunctional protein deficiency
- Miyoshi myopathy
- Muscle filaminopathy
- Myasthenia gravis
- Myopathy and diabetes mellitus
- Plectin-related limb-girdle muscular dystrophy R17
- POMT2-related limb-girdle muscular dystrophy R14
- Postpoliomyelitis syndrome
- Proximal spinal muscular atrophy
- Subacute inflammatory demyelinating polyneuropathy
- Tay-Sachs disease
Sometimes5–29%
11- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Autosomal dominant progressive external ophthalmoplegia
- Calpain-3-related limb-girdle muscular dystrophy R1
- Cap myopathy
- Congenital myasthenic syndrome with glycosylation defect
- Dysferlin-related limb-girdle muscular dystrophy R2
- FKRP-related limb-girdle muscular dystrophy R9
- Glycogen storage disease due to muscle and heart glycogen synthase deficiency
and 3 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.