Rare diseases · Sign or symptom
Severe infection
HP:0032169
What it means
A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection.
Rare diseases that can present with this24
Very common80–99%
10- Bacterial toxic-shock syndrome
- Bickerstaff brainstem encephalitis
- Hemophagocytic syndrome associated with an infection
- Hemorrhagic fever-renal syndrome
- Infection-related hemolytic uremic syndrome
- Lethal ataxia with deafness and optic atrophy
- Pearson syndrome
- Scedosporiosis
- Selective IgM deficiency
- Staphylococcal necrotizing pneumonia
Common30–79%
7Sometimes5–29%
6The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Unusual course of infection
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.