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Start free with EleplanNormosmic congenital hypogonadotropic hypogonadism
ORPHA:432Clinical subtype
Also called Normosmic idiopathic hypogonadotropic hypogonadism · nIHH
What it is
Orphanet has not published a description for this disease yet. The identifiers, classification and cross-references below are still current.
Key facts
- Age of onset
- Infancy, Neonatal
- Inheritance
- Autosomal dominant, Autosomal recessive, Multigenic/multifactorial, X-linked recessive
- Classified as
- Clinical subtype
Recorded for the broader condition
- Prevalence
- 1-9 / 100 000 (at birth)Isolated congenital hypogonadotropic hypogonadism
Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.
Signs and symptoms
Very common80–99%
21- Abnormality of the voice
- Absence of pubertal development
- Absence of secondary sex characteristics
- Azoospermia
- Breast hypoplasia
- Cryptorchidism
- Decreased serum testosterone concentration
- Decreased testicular size
- Delayed skeletal maturation
- Eunuchoid habitus
- Female hypogonadism
- Hypogonadotropic hypogonadism
- Impotence
- Increased female libido
- Male hypogonadism
- Micropenis
- Non-obstructive azoospermia
- Phenotypic abnormality
- Primary amenorrhea
- Sparse body hair
- Wide intermamillary distance
Common30–79%
10These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Benefit programs to look at
Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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