Rare diseases · Sign or symptom
Wide intermamillary distance
Wide-spaced nipples
HP:0006610
What it means
A larger than usual distance between the left and right nipple.
Rare diseases that can present with this66
Very common80–99%
20- 3q13microdeletion syndrome
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome
- Deafness-intellectual disability syndrome, Martin-Probst type
- Difference of sex development-intellectual disability syndrome
- Intellectual disability-polydactyly-uncombable hair syndrome
- Microcephalic primordial dwarfism, Montreal type
- Monosomy 9p syndrome
- Monosomy X syndrome
- Mosaic monosomy X syndrome
- Non-distal duplication 13q syndrome
- Noonan syndrome
- Normosmic congenital hypogonadotropic hypogonadism
- Paternal uniparental disomy of chromosome X syndrome
- Penoscrotal transposition
- Prominent glabella-microcephaly-hypogenitalism syndrome
- Ring chromosome 10 syndrome
- Trisomy 4p syndrome
- Trisomy 9p syndrome
- Turner syndrome
- Turner syndrome due to structural X chromosome anomalies
Common30–79%
23- 19q13.11microdeletion syndrome
- 2p15p16.1microdeletion syndrome
- 2q37microdeletion syndrome
- 8p23.1microdeletion syndrome
- 8q22.1microdeletion syndrome
- Brachyolmia, Maroteaux type
- Braddock syndrome
- Brain malformation-congenital heart disease-postaxial polydactyly syndrome
- Cleft lip/palate-ectodermal dysplasia syndrome
- Combined immunodeficiency with facio-oculo-skeletal anomalies
- Congenital muscular dystrophy-infantile cataract-hypogonadism syndrome
- Distal deletion 9p syndrome
- Fetal hydantoin syndrome
- Fryns syndrome
- Growth delay due to insulin-like growth factor I resistance
- Microcephaly-cardiac defect-lung malsegmentation syndrome
- Monosomy 18p syndrome
- Multiple pterygium-malignant hyperthermia syndrome
- Nicolaides-Baraitser syndrome
- Pierpont syndrome
- SCARF syndrome
- Smith-Lemli-Opitz syndrome
- X-linked intellectual disability, Nascimento type
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Widely spaced nipples · Widely-spaced nipples
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.