Rare diseases · Sign or symptom
Depressed nasal bridge
Depressed bridge of nose
HP:0005280
What it means
Posterior positioning of the nasal root in relation to the overall facial profile for age.
The adjective "depressed" here does not indicate an active process but a status. A depressed nasal bridge can occur irrespective of the width of the nasal bridge, and the width should be assessed independently. In infancy, the nasal bridge is relatively more posterior than in the older person. The term depressed nasal bridge should only be used when the bridge is more posterior than is typical for age and ethnic background.
Rare diseases that can present with this267
Very common80–99%
80- 14q11.2microdeletion syndrome
- 2p21microdeletion syndrome
- 48,XYYY syndrome
- Acrodysostosis
- Alpha-mannosidosis
- Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome
- Aniridia-renal agenesis-psychomotor retardation syndrome
- Apert syndrome
- Autosomal recessive omodysplasia
- Autosomal recessive otospondylomegaepiphyseal dysplasia
- Blepharophimosis-ptosis-epicanthus inversus syndrome
- Blomstrand lethal chondrodysplasia
- Brain malformation-congenital heart disease-postaxial polydactyly syndrome
- Branchioskeletogenital syndrome
- Cataract-hypertrichosis-intellectual disability syndrome
- Char syndrome
- CODAS syndrome
- Coffin-Lowry syndrome
- Cornelia de Lange syndrome
- Costello syndrome
- Crane-Heise syndrome
- Craniodiaphyseal dysplasia
- Craniofacial-deafness-hand syndrome
- Craniometaphyseal dysplasia
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome
- C syndrome
- Cutis gyrata-acanthosis nigricans-craniosynostosis syndrome
- Dermotrichic syndrome
- Desbuquois syndrome
- Diastrophic dysplasia
- Distal deletion 1q syndrome
- Donnai-Barrow syndrome
- Down syndrome
- Dysplastic cortical hyperostosis, Al-Gazali type
- Ectodermal dysplasia-intellectual disability-central nervous system malformation syndrome
- Emery-Nelson syndrome
- Epiphyseal dysplasia-hearing loss-dysmorphism syndrome
- Familial intestinal malrotation
- Fetal minoxidil syndrome
- Fetal trimethadione syndrome
- Fibulo-ulnar hypoplasia-renal anomalies syndrome
- FOXG1 syndrome due to 14q12 microdeletion
- Frank-Ter Haar syndrome
- Frontofacionasal dysplasia
- Frontonasal dysplasia-alopecia-genital anomalies syndrome
- GAPO syndrome
- German syndrome
- Gingival fibromatosis-facial dysmorphism syndrome
- GMS syndrome
- Hartsfield syndrome
- Hennekam syndrome
- Hurler syndrome
- IMAGe syndrome
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Jung syndrome
- Kagami-Ogata syndrome
- Keipert syndrome
- Keutel syndrome
- Kniest dysplasia
- Larsen syndrome
- Léri-Weill dyschondrosteosis
- Marshall syndrome
- Maternal uniparental disomy of chromosome X syndrome
- Maxillonasal dysplasia
- Metatropic dysplasia
- Monosomy 9p syndrome
- Nijmegen breakage syndrome
- Non-distal duplication 10q syndrome
- Opsismodysplasia
- Otofaciocervical syndrome
- Otopalatodigital syndrome type 1
- Otopalatodigital syndrome type 2
- Pai syndrome
- PDE4D haploinsufficiency syndrome
- Pelvic dysplasia-arthrogryposis of lower limbs syndrome
- Penile agenesis
- Pfeiffer syndrome type 1
- Pfeiffer syndrome type 2
- Pfeiffer syndrome type 3
- Progressive non-infectious anterior vertebral fusion
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Concave bridge of nose · Concave nasal bridge · Depressed nasal root · Depressed nasal root/bridge · Flat bridge of nose · Flat nasal bridge · Flat nasal root · Flat, nasal bridge
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.