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Start free with EleplanGrowth delay due to insulin-like growth factor type 1 deficiency
ORPHA:73272Disease
Also called Growth delay-deafness-intellectual disability syndrome · Growth delay-hearing loss-intellectual disability syndrome · IGF-1 deficiency · Primary insulin-like growth factor deficiency
What it is
Growth delay due to insulin-like growth factor I deficiency is characterised by the association of intrauterine and postnatal growth retardation with sensorineural deafness and intellectual deficit.
Key facts
- Prevalence
- <1 / 1 000 000
- Age of onset
- Antenatal, Infancy, Neonatal
- Inheritance
- Autosomal recessive
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
20- Abnormal facial shape
- Attention deficit hyperactivity disorder
- Atypical behavior
- Bilateral sensorineural hearing impairment
- Congenital sensorineural hearing impairment
- Failure to thrive
- Hyperactivity
- Insulin resistance
- Intellectual disability
- Intellectual disability, mild
- Intrauterine growth retardation
- Microcephaly
- Postnatal growth retardation
- Prelingual sensorineural hearing impairment
- Sensorineural hearing impairment
- Severe intrauterine growth retardation
- Severe postnatal growth retardation
- Short attention span
- Short stature
- Small for gestational age
Common30–79%
10Sometimes5–29%
12- Cafe-au-lait spot
- Concave nasal ridge
- Congenital bilateral ptosis
- Hypoglycemia
- Low anterior hairline
- Low posterior hairline
- Motor delay
- Myopia
and 4 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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