Rare diseases · Sign or symptom
Insulin resistance
Body fails to respond to insulin
HP:0000855
What it means
Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels.
Rare diseases that can present with this39
Always100%
3Very common80–99%
13- Acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome
- Acquired generalized lipodystrophy
- Alström syndrome
- Autosomal semi-dominant severe lipodystrophic laminopathy
- Congenital generalized lipodystrophy
- Donohue syndrome
- Familial partial lipodystrophy, Dunnigan type
- Familial partial lipodystrophy, Köbberling type
- Growth delay due to insulin-like growth factor type 1 deficiency
- Insulin autoimmune syndrome
- Insulin-resistance syndrome type B
- Mandibuloacral dysplasia
- Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome
Common30–79%
11The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.