Rare diseases · Sign or symptom
Anti-dsDNA antibody positivity
HP:0020151
What it means
The presence of autoantibodies (immunoglobulins) in the serum that react against double-stranded DNA.
Anti-DNA antibodies can be observed in persons with systemic lupus erythematosus (SLE), being a formal classification criterion.
Rare diseases that can present with this9
Common30–79%
3Sometimes5–29%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Anti-double-stranded DNA antibody positivity
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.