Rare diseases · Sign or symptom
Recurrent upper respiratory tract infections
Recurrent colds
HP:0002788
What it means
An increased susceptibility to upper respiratory tract infections as manifested by a history of recurrent upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).
Rare diseases that can present with this43
Very common80–99%
10- 48,XYYY syndrome
- 49,XXXYY syndrome
- 49,XYYYY syndrome
- Deficiency in anterior pituitary function-variable immunodeficiency syndrome
- Distal Xq28 microduplication syndrome
- Lethal ataxia with deafness and optic atrophy
- Mucopolysaccharidosis type 6
- Netherton syndrome
- Progressive myoclonic epilepsy with dystonia
- STAT1-related autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome
Common30–79%
23- Alström syndrome
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Coffin-Siris syndrome
- COG4-CDG
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome
- Congenital tracheomalacia
- Familial nasal acilia
- FOXP1 Syndrome
- Menke-Hennekam syndrome
- Mucopolysaccharidosis type 2
- Nasopalpebral lipoma-coloboma syndrome
- Obesity due to congenital leptin deficiency
- Obesity due to leptin receptor gene deficiency
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
- Selective IgM deficiency
- Severe X-linked intellectual disability, Gustavson type
- Smith-Magenis syndrome
- Sporadic infantile bilateral striatal necrosis
- T-B-NK- severe combined immunodeficiency due to adenosine deaminase deficiency
- Trisomy 8p syndrome
- WHIM syndrome
- Xq12-q13.3 duplication syndrome
Sometimes5–29%
10- Bilateral acute depigmentation of the iris
- Dyggve-Melchior-Clausen disease
- Farber disease
- Helsmoortel-Van der Aa syndrome
- Isolated tracheoesophageal fistula
- Mucolipidosis type III alpha/beta
- PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome
- Recurrent respiratory papillomatosis
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Frequent upper respiratory infections · Frequent upper respiratory tract infections · Recurrent upper respiratory and lower respiratory infections · Recurrent upper respiratory infection · Recurrent upper respiratory infections · Recurrent URI · Upper respiratory tract infections · Upper respiratory tract infections, recurrent
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.