Rare diseases · Sign or symptom
Recurrent respiratory infections
Frequent respiratory infections
HP:0002205
What it means
An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.
Rare diseases that can present with this176
Very common80–99%
45- Activated PI3K-delta syndrome 1
- Alopecia antibody deficiency
- Ataxia-telangiectasia
- Attenuated Chédiak-Higashi syndrome
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Autosomal non-syndromic agammaglobulinemia
- Autosomal recessive malignant osteopetrosis
- Beta-mannosidosis
- Chronic granulomatous disease
- Cleidocranial dysplasia
- Combined immunodeficiency due to DOCK8 deficiency
- Cortical blindness-intellectual disability-polydactyly syndrome
- Cystic fibrosis
- Cystic fibrosis-gastritis-megaloblastic anemia syndrome
- Encephalopathy due to prosaposin deficiency
- Felty syndrome
- Glycogen storage disease due to glucose-6-phosphatase deficiency
- Granulomatosis with polyangiitis
- Harlequin ichthyosis
- Hereditary mucoepithelial dysplasia
- Hereditary sensory and autonomic neuropathy due to TECPR2 mutation
- Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary dyskinesia syndrome
- Hypomandibular faciocranial dysostosis
- ICF syndrome
- Immunodeficiency by defective expression of MHC class II
- Imperforate oropharynx-costovertebral anomalies syndrome
- Jung syndrome
- Larynx atresia
- Macrosomia-microphthalmia-cleft palate syndrome
- Microcephalic primordial dwarfism, Toriello type
- Mounier-Kühn syndrome
- Mucopolysaccharidosis-like syndrome with congenital heart defects and hematopoietic disorders
- Mucopolysaccharidosis type 7
- Nijmegen breakage syndrome
- Non-syndromic agammaglobulinemia
- Orofaciodigital syndrome type 4
- Paroxysmal cold hemoglobinuria
- PGM3-CDG
- Prolidase deficiency
- Reticular dysgenesis
- Selective IgM deficiency
- Short-limb skeletal dysplasia with severe combined immunodeficiency
- Vici syndrome
- Wiskott-Aldrich syndrome
- X-linked intellectual disability, Pai type
Common30–79%
35- 13q12.3microdeletion syndrome
- 19q13.11microdeletion syndrome
- 2p15p16.1microdeletion syndrome
- 3C syndrome
- 48,XXXY syndrome
- 48,XXYY syndrome
- 49,XXXXY syndrome
- Abnormal origin of right or left pulmonary artery from the aorta
- Absence of the pulmonary artery
- Activated PI3K-delta syndrome 2
- ALG12-CDG
- Allan-Herndon-Dudley syndrome
- Ataxia-pancytopenia syndrome
- Atrial septal defect, ostium primum type
- Blepharophimosis-intellectual disability syndrome, SBBYS type
- Bohring-Opitz syndrome
- Chédiak-Higashi syndrome
- Cleft lip/palate-ectodermal dysplasia syndrome
- Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome
- Congenital myasthenic syndrome
- Congenital myopathy with myasthenic-like onset
- Cryptorchidism-arachnodactyly-intellectual disability syndrome
- Cystic hamartoma of lung and kidney
- Diastrophic dysplasia
- Dyskeratosis congenita
- Dysmorphism-short stature-deafness-difference of sex development syndrome
- Early infantile developmental and epileptic encephalopathy
- Emanuel syndrome
- Esophageal atresia
- Familial dysautonomia
- Free sialic acid storage disease
- GATA2 deficiency spectrum
- Gaucher disease type 2
- Glycogen storage disease due to acid maltase deficiency
- Hennekam syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Multiple respiratory infections · respiratory infections, recurrent · Susceptibility to respiratory infections
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.