Rare diseases · Sign or symptom
Recurrent fractures
Increased fracture rate
HP:0002757
What it means
The repeated occurrence of bone fractures (implying an abnormally increased tendency for fracture).
This term will be made obsolete. The annotations need to be checked.
Rare diseases that can present with this60
Very common80–99%
20- Albers-Schönberg osteopetrosis
- Autosomal recessive malignant osteopetrosis
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Bruck syndrome
- Campomelic dysplasia
- Congenital osteogenesis imperfecta-microcephaly-cataracts syndrome
- Dent disease
- Dermatitis herpetiformis
- Dysosteosclerosis
- Familial osteodysplasia, Anderson type
- Geroderma osteodysplastica
- Homocystinuria due to cystathionine beta-synthase deficiency
- Hypocalcemic vitamin D-resistant rickets
- Idiopathic juvenile osteoporosis
- Infantile systemic hyalinosis
- Juvenile Paget disease
- Neonatal severe primary hyperparathyroidism
- Osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome
- Spastic paraplegia-Paget disease of bone syndrome
- Urban-Rogers-Meyer syndrome
Common30–79%
22- Achondrogenesis type 1A
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Cole-Carpenter syndrome
- Congenital insensitivity to pain with severe intellectual disability
- Dermatosparaxis Ehlers-Danlos syndrome
- Dyskeratosis congenita
- Gaucher disease
- Hajdu-Cheney syndrome
- Hallermann-Streiff syndrome
- Hypergonadotropic hypogonadism-cataract syndrome
- Hypogonadotropic hypogonadism-retinitis pigmentosa syndrome
- Hypophosphatasia
- Intermediate osteopetrosis
- Lethal congenital contracture syndrome type 1
- Neurofibromatosis type 1
- Oculocerebrorenal syndrome of Lowe
- Osteogenesis imperfecta
- Osteopenia-intellectual disability-sparse hair syndrome
- Osteopetrosis with renal tubular acidosis
- Paternal uniparental disomy of chromosome 1 syndrome
- Primary hyperoxaluria
- Stüve-Wiedemann syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Frequent fractures · Increased fractures · Multiple fractures · Multiple spontaneous fractures · Varying degree of multiple fractures
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.