Rare diseases · Sign or symptom
Increased susceptibility to fractures
Abnormal susceptibility to fractures
HP:0002659
What it means
An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture.
This is a bundled term that will be made obsolete.
Rare diseases that can present with this40
Very common80–99%
6Common30–79%
15- Alacrimia-choreoathetosis-liver dysfunction syndrome
- Arthrochalasia Ehlers-Danlos syndrome
- Beta-thalassemia intermedia
- Classic pantothenate kinase-associated neurodegeneration
- Fibrodysplasia ossificans progressiva
- Hypophosphatasia
- Intermediate osteopetrosis
- Marshall-Smith syndrome
- Oncogenic osteomalacia
- Osteogenesis imperfecta
- Prader-Willi syndrome
- Primary Fanconi renotubular syndrome
- Pycnodysostosis
- Pyle disease
- Spondylodysplastic Ehlers-Danlos syndrome
Sometimes5–29%
17- Alkaptonuria
- Brittle cornea syndrome
- Cerebrotendinous xanthomatosis
- Craniopharyngioma
- Cushing syndrome due to bilateral macronodular adrenocortical disease
- Distal renal tubular acidosis
- Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
- Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
and 9 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Bone fragility · Frequent broken bones · Increased bone fragility · Increased tendency to fractures
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.