Familial papillary or follicular thyroid…

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Familial papillary or follicular thyroid carcinoma

ORPHA:319487Disease

Also called FNMTC · Familial pure nonmedullary thyroid carcinoma

What it is

Familial papillary or follicular thyroid carcinoma is a rare, hereditary nonmedullary thyroid carcinoma characterized by the presence of differentiated thyroid cancer of follicular cell origin in two or more first-degree relatives, in the absence of other familial tumor syndromes or radiation exposure. Frequent capsular invasion is observed. Biopsy reveals multicentric tumors with multiple adenomatous nodules with or without oxyphilia and follicular or papillary carcinoma histology.

Key facts

Age of onset
Adult
Inheritance
Not applicable
Classified as
Disease

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Genes

FOXE1Disease-causing germline mutation(s)
HABP2Disease-causing germline mutation(s)
MINPP1Candidate gene tested

ICD-10 codes

C73filed under a broader ICD-10 category — shared with 5 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 8488MONDO 0017895OMIM 188470OMIM 188550OMIM 603386OMIM 603744OMIM 606240OMIM 616534OMIM 616535

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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