Rare diseases · Sign or symptom
Highly arched eyebrow
Arched eyebrows
HP:0002553
What it means
Increased height of the central portion of the eyebrow, forming a crescent, semicircular, or inverted U shape.
Most eyebrows have some arch with downturning medially and laterally.
Rare diseases that can present with this87
Very common80–99%
22- 3MC syndrome
- 8q22.1microdeletion syndrome
- Baraitser-Winter cerebrofrontofacial syndrome
- Blepharophimosis-ptosis-esotropia-syndactyly-short stature syndrome
- Branchioskeletogenital syndrome
- Cognitive impairment-coarse facies-heart defects-obesity-pulmonary involvement-short stature-skeletal dysplasia syndrome
- Cornelia de Lange syndrome
- Distal 22q11.2 microdeletion syndrome
- Flat face-microstomia-ear anomaly syndrome
- Hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome
- Kabuki syndrome
- Kleefstra syndrome due to 9q34 microdeletion
- Prominent glabella-microcephaly-hypogenitalism syndrome
- Ptosis-upper ocular movement limitation-absence of lacrimal punctum syndrome
- Ring chromosome 7 syndrome
- Rubinstein-Taybi syndrome due to CREBBP mutations
- Rubinstein-Taybi syndrome due to EP300 haploinsufficiency
- Severe intellectual disability-epilepsy-anal anomalies-distal phalangeal hypoplasia
- SPECC1L-related hypertelorism syndrome
- Trisomy 18p syndrome
- Trisomy 20p syndrome
- Wolf-Hirschhorn syndrome
Common30–79%
34- 14q11.2microdeletion syndrome
- 20p13microdeletion syndrome
- 2q23.1microdeletion syndrome
- 2q23.1microduplication syndrome
- 2q37microdeletion syndrome
- 8p23.1duplication syndrome
- 8q12microduplication syndrome
- 9q31.1q31.3microdeletion syndrome
- 9q33.3q34.11microdeletion syndrome
- Autism spectrum disorder due to AUTS2 deficiency
- Birk-Barel syndrome
- CHST3-related skeletal dysplasia
- Cleft lip/palate-ectodermal dysplasia syndrome
- Dysmorphism-short stature-deafness-difference of sex development syndrome
- Early-onset seizures-distal limb anomalies-facial dysmorphism-global developmental delay syndrome
- Focal facial dermal dysplasia type III
- Intellectual disability-muscle weakness-short stature-facial dysmorphism syndrome
- Juberg-Hayward syndrome
- Kleefstra syndrome
- Menke-Hennekam syndrome
- Monosomy 9p syndrome
- Nicolaides-Baraitser syndrome
- Non-syndromic metopic craniosynostosis
- Pierre-Robin sequence-Manzke dysostosis-clinodactyly of the index finger syndrome
- Pontocerebellar hypoplasia type 10
- Pseudoaminopterin syndrome
- Pterygium colli-intellectual disability-digital anomalies syndrome
- Ring chromosome 2 syndrome
- Rubinstein-Taybi syndrome
- Schuurs-Hoeijmakers syndrome
- Severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome
- Weiss-Kruszka Syndrome
- X-linked intellectual disability, Najm type
- Xq25microduplication syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Bowed and upward slanting eyebrows · Broad, arched eyebrows · High arched eyebrows · High, rounded eyebrows · High-arched eyebrows · Thick, flared eyebrows
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.