Liddle syndrome

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Liddle syndrome

ORPHA:526Disease

Also called Pseudoaldosteronism

What it is

A rare genetic form of low-renin hypertension characterized by hypertension associated with decreased plasma levels of potassium and aldosterone.

Key facts

Age of onset
Adolescent, Adult, Childhood, Infancy
Inheritance
Autosomal dominant
Classified as
Disease

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Genes

SCNN1ADisease-causing germline mutation(s) (gain of function)
SCNN1BDisease-causing germline mutation(s) (gain of function)
SCNN1GDisease-causing germline mutation(s) (gain of function)

ICD-10 codes

I15.1filed under a broader ICD-10 category — shared with 8 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Benefit programs to look at

Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.

Cross-references

GARD 7381MEDDRA 10052313MESH D056929MONDO 0008323OMIM 177200OMIM 618114OMIM 618126UMLS C0221043

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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